| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[50] PMTCT(risk-stratified): Beste S, Essajee S, Siberry G, Hannaford A, Dara J, Sugandhi N, Penazzato M. Optimal Antiretroviral Prophylaxis in Infants at High Risk of Acquiring HIV: A Systematic Review. Pediatr Infect Dis J. 2018 Feb;37(2):169-175. https://www.ncbi.nlm.nih.gov/pubmed/29319636
PMTCT(risk-stratified): National Department of Health, Essential Drugs Programme: Paediatric Hospital Level STGs and EML, 2020 (draft). http://www.health.gov.za/
PMTCT(risk-stratified): World Health Organisation. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection, 2016. https://www.ncbi.nlm.nih.gov/pubmed/29319636