| Level I | Good quality evidence |
Systematic review of RCTs with consistent findings High quality individual RCT |
| Level II |
Limited quality patient orientated evidence |
Systematic review of lower quality studies or studies with inconsistent findings Low quality clinical trial Cohort studies Case-control studies |
| Level III | Other |
Consensus guidelines, extrapolations from bench research, usual practice, opinion, disease-oriented evidence (intermediate or physiologic outcomes only), or case series |
[35] Cotrimoxazole, oral: National Department of Health: Affordable Medicines, EDP-Adult Hospital level. Medicine review: CD4 cut‐off for cotrimoxazole for OI prophylaxis in PLHIV, May 2017. http://www.health.gov.za/
Cotrimoxazole, oral: Grimwade K, Swingler, G. Cotrimoxazole prophylaxis for opportunistic infections in adults with HIV. Cochrane Database Syst Rev. 2003;(3):CD003108. http://www.ncbi.nlm.nih.gov/pubmed/12917946